Publications by authors named "G J Rojas"
Mitochondrial retrograde signaling (MRS) pathways relay the functional status of mitochondria to elicit homeostatic or adaptive changes in nuclear gene expression. Budding yeast have "intergenomic signaling" pathways that sense the amount of mitochondrial DNA (mtDNA) independently of oxidative phosphorylation (OXPHOS), the primary function of genes encoded by mtDNA. However, MRS pathways that sense the amount of mtDNA in mammalian cells remain poorly understood.
View Article and Find Full Text PDFNitrite is usual in water of intensive rearing systems. Considering its oxidative harmful potential, it was selected to challenge matrinxa Brycon amazonicus reared in sustained swimming (SS) (with flowing water adjusted to speed at 1.0 BL seg (long-duration aerobic metabolic characteristic) and evaluate any beneficial effect of such rearing system to enhance the fish potential to cope with this oxidant stressor in fish farmings.
View Article and Find Full Text PDFUnlabelled: Eighty percent of depressed patients in Primary Health Care (PHC) have a comorbidity. It is essential to contribute local evidence on the characteristics of patients with physical and psychiatric comorbidities to better address clinical practice.
Aim: To characterize depressed patients from the cardiovascular program (PCV) of eight family health centers (CESFAM) in two communes of the Metropolitan Region.
Article Synopsis
- Gene expression is influenced by epigenetics and varies based on the cellular environment, with recent advancements in spatial omics enhancing our understanding of this context.
- The introduction of DBiT-seq offers a pioneering method for spatial epigenomic profiling at the cellular level, significantly improving cell typing and identification of regulatory elements.
- The new 96-channel microfluidics chip provides more precise spatial mapping of brain cells, revealing the intricate organization of glial and neuronal cells and the regulatory mechanisms that affect development and disease.
Article Synopsis
- Understanding how the immune system responds to SARS-CoV-2 is essential for developing effective treatments and understanding long-term immunity.
- The study focused on measuring specific antibody responses (anti-RBD IgG) in unvaccinated individuals recovered from COVID-19 in Cuba, using ELISA methods to quantify antibody levels.
- Findings indicated that those who experienced severe illness had significantly higher antibody levels and blocking abilities, while the antibody response generally declined over four months, showing that severity of disease is a key factor in the immune response.