Publications by authors named "G J Quigley"
Remodelling and dysfunction of the sinus node in pulmonary arterial hypertension.
Philos Trans R Soc Lond B Biol Sci
June 2023
Patients with pulmonary arterial hypertension (PAH) have a high burden of arrhythmias, including arrhythmias arising from sinus node dysfunction, and the aim of this study was to investigate the effects of PAH on the sinus node. In the rat, PAH was induced by an injection of monocrotaline. Three weeks after injection, there was a decrease of the intrinsic heart rate (heart rate in the absence of autonomic tone) as well as the normal heart rate, evidence of sinus node dysfunction.
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- Purkinje fibers (PFs) are critical for coordinating heart contractions and their dysfunction is linked to arrhythmias in heart failure (HF) patients.
- *In a study using various advanced techniques, researchers induced HF in rabbits, revealing significant changes in PF function, including prolonged electrical intervals and alterations in ion channel expression.
- *Results showed that HF leads to structural and electrical remodeling of the PF network, contributing to disrupted heart rhythm and impaired ventricular responsiveness.
Atrioventricular Node Dysfunction and Ion Channel Transcriptome in Pulmonary Hypertension.
Circ Arrhythm Electrophysiol
December 2016
Background: Heart block is associated with pulmonary hypertension, and the aim of the study was to test the hypothesis that the heart block is the result of a change in the ion channel transcriptome of the atrioventricular (AV) node.
Methods And Results: The most commonly used animal model of pulmonary hypertension, the monocrotaline-injected rat, was used. The functional consequences of monocrotaline injection were determined by echocardiography, ECG recording, and electrophysiological experiments on the Langendorff-perfused heart and isolated AV node.