Publications by authors named "G J Offerhaus"
Article Synopsis
- Detection of lymphovascular invasion (LVI) in T1 colorectal cancer (CRC) varies across Dutch laboratories and significantly influences treatment decisions, particularly surgical resection rates.
- Patients diagnosed in laboratories with high LVI detection rates had higher surgical resection rates and a greater proportion of lymph node metastasis-negative surgeries compared to those from lower detection rate labs.
- However, despite these differences in surgical approach, high LVI detection did not lead to significantly better cancer recurrence outcomes, indicating potential risks without improved benefits for patients.
Patients with long-standing inflammatory bowel disease (IBD) face an increased risk of developing colitis-associated cancer (CAC). Although IBD-induced prolonged inflammation seems to be involved in CAC pathogenesis, the specific molecular changes that contribute remain unknown. Here, we applied digital spatial RNA profiling, RNAscope, and imaging mass cytometry to examine paired uninflamed, inflamed, and early dysplastic mucosa of patients with IBD.
View Article and Find Full Text PDFBackground: The role of radiological staging and surveillance imaging is under debate for T1 colorectal cancer (CRC) as the risk of distant metastases is low and imaging may lead to the detection of incidental findings.
Objective: The aim of this study was to evaluate the yield of radiological staging and surveillance imaging for T1 CRC.
Methods: In this retrospective multicenter cohort study, all patients of 10 Dutch hospitals with histologically proven T1 CRC who underwent radiological staging in the period 2000-2014 were included.
Background: The recently identified classical and basal-like molecular subtypes of pancreatic cancer impact on overall survival (OS). However, the added value of routine subtyping in both clinical practice and randomized trials is still unclear, as most studies do not consider clinicopathological parameters. This study examined the clinical prognostic value of molecular subtyping in patients with resected pancreatic cancer.
View Article and Find Full Text PDFIn 2021 it was 100 years since drPeutz published his case report titled: 'a very remarkable case of familial polyposis of mucous membranes of intestinal tract and nasopharynx accompanied by peculiar pigmentations of skin and mucous membrane'. This is the first description of the Peutz-Jeghers syndrome, which is named after him. Like Peutz already suggested a century ago, we know now that this is a genetic disorder (autosomal dominant) caused by mutations in the STK11 gene.
View Article and Find Full Text PDF