Publications by authors named "G J Nieuwenhuijs-Moeke"
Living donor kidney transplantation boasts superior patient and graft survival rates compared to deceased donor kidney transplantation. However, the impact of living donor body composition (BC) on post-transplant kidney function remains uncertain. In a cohort of 293 living kidney donor-recipients pairs, we utilized linear mixed model analyses, adjusted for time and including a multiplicative interaction term of time with the donor body composition measure, and found no significant associations between any donor BC measure and the annual change in recipient post-transplantation estimated glomerular filtration rate (eGFR) [donor body mass index (BMI): =-0.
View Article and Find Full Text PDFKidney transplantation is the best treatment for kidney failure in older patients. However, little is known regarding changes in health-related quality of life (HRQoL) from before to after transplantation and determinants of HRQoL in older kidney transplant recipients (KTR). We studied both, using data of older (≥65 years) patients waitlisted for kidney transplantation and older KTR 1 year after transplantation from the TransplantLines Biobank and Cohort Study.
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- Targeted temperature management (TTM) during cardiopulmonary bypass (CPB) affects neuroinflammation and cold shock protein expression in rats, with comparisons made between mild (33°C) and deep hypothermia (18°C).
- PET scan analyses showed higher neuroinflammatory response in key brain regions (amygdala and hippocampus) at 7 days in the deep hypothermia group compared to mild hypothermia, although there were no differences in specific cytokine expressions.
- Mild hypothermia (33°C) was associated with elevated levels of cold shock proteins RBM3 and TrkB in the brain, suggesting it may offer neuroprotective benefits compared to deep hypothermia during CPB