Avatrombopag for severe refractory thrombocytopenia in a pediatric patient with ALL following allogeneic hematopoietic stem cell transplantation: A case report.

Patients who receive allogeneic hematopoietic stem cell transplantation (alloHSCT) are at risk for developing persistent thrombocytopenia. Here, we describe treatment with avatrombopag, a thrombopoietin receptor agonist, in a pediatric patient with chronic, severe, transfusion-dependent thrombocytopenia (<10 × 10/µL) post-alloHSCT that was persistent despite treatment with romiplostim, another thrombopoietin receptor agonist. Following the granting of a compassionate use investigational new drug authorization, avatrombopag treatment was initiated, and the patient's platelet count increased.

Feasibility study of busulfan, fludarabine, and thiotepa conditioning regimen for allogeneic hematopoietic stemcell transplantationfor children and young adults with nonmalignant disorders.

Background: Hematopoietic stem cell transplant (HSCT) is the only curative treatment for several pediatric non-malignant disorders. A widely used conditioning backbone is busulfan, fludarabine, and rabbit anti-thymocyte globulin (rATG). Thiotepa has improved engraftment when added to this regimen, however the minimum effective dose (MED) of thiotepa to achieve engraftment while minimizing toxicities has not been well established.

Radiation options for early stage breast cancer.

Objective: To explore the current radiation therapy options for early stage breast cancer.

Data Sources: Research literature and review articles.

Conclusion: With 20 years of clinical data supporting the efficacy of whole breast radiotherapy after lumpectomy for early stage breast cancer, the attention has shifted to an even more conservative approach, namely partial breast irradiation following lumpectomy.

The role of licensed nursing personnel in radiation oncology part B: integrating the ambulatory care nursing conceptual framework.

Purpose/objectives: To describe the professional opportunities for licensed nursing personnel in radiation oncology within the conceptual framework developed for ambulatory care nurses by the American Academy of Ambulatory Care Nursing (AAACN).

Data Sources: Published articles and books.

Data Synthesis: Using AAACN's framework, the researchers identified three roles that are part of every ambulatory care nurse's practice and can be readily customized to radiation oncology: an organizational/systems role, a professional role, and a clinical nursing role.

The role of licensed nursing personnel in radiation oncology part a: results of a descriptive study.

Purpose/objectives: To identify the specific administrative, clerical, patient care, patient education, and research responsibilities that licensed nursing personnel perform in the field of radiation oncology.

Design: Descriptive.

Sample: 281 licensed nursing personnel employed in the field of radiation oncology in North America.