Discovery of novel hybrid tryptamine-rivastigmine molecules as potent AChE and BChE inhibitors exhibiting multifunctional properties for the management of Alzheimer's disease.

Contemporary research evidence has corroborated a gradual loss of central cholinergic neurons in Alzheimer's Disease (AD). This progressive deterioration leads to cognitive dysfunction and impaired motor activity, culminating in the brain cell's death in the disease. The approved drugs for AD treatment can only offer relief from symptoms without addressing the underlying pathological hallmarks of the disease.

Electrically driven long-range solid-state amorphization in ferroic InSe.

Electrically induced amorphization is uncommon and has so far been realized by pulsed electrical current in only a few material systems, which are mostly based on the melt-quench process. However, if the melting step can be avoided and solid-state amorphization can be realized electrically, it opens up the possibility for low-power device applications. Here we report an energy-efficient, unconventional long-range solid-state amorphization in a new ferroic β″-phase of indium selenide nanowires through the application of a direct-current bias rather than a pulsed electrical stimulus.