Publications by authors named "G J Mishkel"

Article Synopsis
  • - The study examines the rising prevalence of coronary artery disease (CAD) in adults with chronic limb-threatening ischemia (CLTI) from 2000 to 2018, finding that about 23% of CLTI patients also had CAD, which increased over the years from 15.3% to 23.1%.
  • - It reports that individuals with CLTI and CAD have a higher risk of in-hospital mortality and complications, such as bleeding requiring transfusion, compared to those without CAD.
  • - The research highlights a shift in treatment methods, showing an increase in endovascular procedures over surgical ones for patients with both CAD and CLTI, and suggests a need for improved interventions for this vulnerable group.
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Importance: Long-term follow-up after transcatheter aortic valve replacement (TAVR) is of interest given that longitudinal data on mortality and durability of transcatheter heart valves are limited. The REPRISE III (Repositionable Percutaneous Replacement of Stenotic Aortic Valve Through Implantation of Lotus Valve System-Randomized Clinical Evaluation) randomized clinical trial compared the mechanically expanded Lotus valve with the self-expanding CoreValve/EvolutR TAVR platforms.

Objective: To describe the final 5-year outcomes of the REPRISE III trial.

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Article Synopsis
  • The study aimed to compare the effectiveness and safety of P2Y inhibitors versus aspirin alone for preventing further heart problems in patients with atherosclerotic cardiovascular disease (ASCVD).
  • Researchers analyzed 9 randomized trials involving over 61,000 patients, focusing on major adverse cardiac events (MACE) and other outcomes like myocardial infarction (MI), stroke, and major bleeding.
  • Results showed P2Y inhibitors reduced the risk of MACE by 11% and MI by 19% compared to aspirin, with no significant difference in stroke, all-cause mortality, or major bleeding, suggesting P2Y inhibitors may be a better option for secondary prevention.
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Background As transcatheter aortic valve replacement expands to younger and/or lower risk patients, the long-term consequences of permanent pacemaker implantation are a concern. Pacemaker dependency and impact have not been methodically assessed in transcatheter aortic valve replacement trials. We report the incidence and predictors of pacemaker implantation and pacemaker dependency after transcatheter aortic valve replacement with the Lotus valve.

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