Feasibility studies of multimodal nonlinear endoscopy using multicore fiber bundles for remote scanning from tissue sections to bulk organs.

Here, we report on the development and application of a compact multi-core fiber optical probe for multimodal non-linear imaging, combining the label-free modalities of Coherent Anti-Stokes Raman Scattering, Second Harmonic Generation, and Two-Photon Excited Fluorescence. Probes of this multi-core fiber design avoid moving and voltage-carrying parts at the distal end, thus providing promising improved compatibility with clinical requirements over competing implementations. The performance characteristics of the probe are established using thin cryo-sections and artificial targets before the applicability to clinically relevant samples is evaluated using ex vivo bulk human and porcine intestine tissues.

Relational local electroencephalography representations for sleep scoring.

Computational sleep scoring from multimodal neurophysiological time-series (polysomnography PSG) has achieved impressive clinical success. Models that use only a single electroencephalographic (EEG) channel from PSG have not yet received the same clinical recognition, since they lack Rapid Eye Movement (REM) scoring quality. The question whether this lack can be remedied at all remains an important one.

Multimodal nonlinear endomicroscopic imaging probe using a double-core double-clad fiber and focus-combining micro-optical concept.

Multimodal non-linear microscopy combining coherent anti-Stokes Raman scattering, second harmonic generation, and two-photon excited fluorescence has proved to be a versatile and powerful tool enabling the label-free investigation of tissue structure, molecular composition, and correlation with function and disease status. For a routine medical application, the implementation of this approach into an in vivo imaging endoscope is required. However, this is a difficult task due to the requirements of a multicolour ultrashort laser delivery from a compact and robust laser source through a fiber with low losses and temporal synchronization, the efficient signal collection in epi-direction, the need for small-diameter but highly corrected endomicroobjectives of high numerical aperture and compact scanners.

Continuous Heart Rate Monitoring for Automatic Detection of Life-Threatening Arrhythmias With Novel Bio-Sensing Technology.

Assessing the effectiveness of novel bio-sensing technology (CardiacSense), for accuracy and reliability of automatic detection of life-threatening arrhythmias. This prospective study consisted of Eighteen patients (13 males and 5 females, mean age 59.4 ± 21.

Reliable profile reconstruction of GRIN lenses produced by ion-exchange processes.

We propose a method that allows for a fast and accurate reconstruction of the refractive index profile of radially symmetric gradient index lenses fabricated by ion-exchange processes. The presented method enables the reconstruction of the profile up to the 10th polynomial order without direct spatially resolved refractive index measurements. It requires as input a working distance measurement at the paraxial limit and an accurate wavefront aberration measurement at full aperture.