Publications by authors named "G J Lammers"
Shift work can cause circadian misalignment, which often results in sleeping problems and has been associated with immune dysfunction. To better understand the impact of shift work on a primary immune response to vaccination, we compared severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-specific humoral and cellular immune responses after one injection of the messenger RNA (mRNA)-1273 vaccine between day workers (n = 24) and night shift workers (n = 21). In addition, duration and quality of sleep were assessed for a period of 7 days around the time of vaccination using actigraphy and daily sleep diaries, and their relationship with immunogenicity of mRNA-1273 vaccination was studied.
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- - Narcolepsy type 1 (NT1) is characterized by low hypocretin levels and changes in stress hormone activity, particularly a loss of corticotrophin-releasing hormone (CRH) linked to the body's stress response system.
- - A study involving NT1 patients and healthy controls utilized the Trier Social Stress Test to measure physiological and psychological responses to stress, including changes in ACTH, cortisol, heart rate, and subjective stress levels.
- - Results indicated participants with NT1 felt more stressed, but their hormone and heart rate responses were similar to controls, although men with NT1 had notably lower cortisol levels after stress than their control counterparts, suggesting further exploration is necessary for understanding CRH's role and gender effects
Article Synopsis
- Hypocretin deficiency leads to type 1 narcolepsy, which is associated with excessive daytime sleepiness and a high prevalence of overweight and obesity in patients.
- A study compared energy expenditure in ten males with narcolepsy to nine healthy controls using respiration chamber calorimetry and doubly labelled water.
- Results showed no significant differences in energy expenditure or physical activity between the two groups, suggesting that weight gain in narcolepsy might be influenced by factors other than metabolism, such as dietary habits.
Article Synopsis
- * Researchers analyzed data from over 1500 patients and found that women reported higher sleepiness on the Epworth Sleepiness Scale compared to men, with specific age-related trends observed in different patient groups.
- * Notably, in women with narcoleptic conditions, an increase in daytime sleepiness was linked to age, while weight gain appeared later, suggesting a complex relationship that warrants further research for targeted treatment approaches.
Article Synopsis
- * There's a possibility that an autoimmune process is involved, but tests for specific autoantibodies and T-cells haven't provided clear answers; other factors, like reduced hormone production in the brain, are also being considered.
- * Currently, there is no cure for NT1, and treatment focuses on managing symptoms; however, new hypocretin receptor agonists are showing promise in clinical trials, highlighting the need for better understanding and early diagnosis to improve treatment outcomes, especially in children