Publications by authors named "G J Kaspers"
Clinical pharmacology studies are critical for determining the efficacy and safety of drugs. Due to the resource-intensive nature of these studies, most have been conducted in high-income countries, leading to a significant gap in clinical pharmacology data for patients in low- and middle-income countries. This paper provides an overview of the minimal requirements for performing a clinical pharmacology investigator-initiated trial (IIT), including pharmacokinetic sampling.
View Article and Find Full Text PDFArticle Synopsis
- Pediatric brain tumors in low- and middle-income countries, particularly Western Kenya, are less studied than other pediatric cancers, and effective care relies on collaboration among multiple medical departments.
- The study found that, between 2015 and 2022, 79 children were diagnosed with brain tumors, primarily medulloblastoma, with a low 2-year event-free survival rate of 13% and a significant treatment abandonment rate of 46%.
- Improvements in multidisciplinary care were noted from 2020 to 2022, influenced by factors such as resources, knowledge, and relationships among healthcare workers; addressing these barriers is essential for enhancing patient outcomes.
Background: Intrathecal (IT) chemotherapy is essential in treating hematological malignancies, but it can lead to ascending paraplegia, a condition that currently lacks clear management guidelines.
Methods: We conducted a systematic review, analyzing 1219 studies and 116 patients, adhering to PRISMA guidelines for individual patient data. The study, registered under PROSPERO (CRD42022362121), focused on the onset, diagnostic approaches, and therapeutic interventions associated with this complication, and management strategies to tackle the ascending paraplegia.
Introduction: Sub-Saharan Africa is facing a severe crisis in human resources for health. Primary healthcare is the most affected. This problem is aggravated by absenteeism, implying that healthcare workers are absent on duty during scheduled working hours.
View Article and Find Full Text PDFCharacterization of Pediatric Acute Myeloid Leukemia With t(7;12)(q36;p13).
Genes Chromosomes Cancer
November 2024
Article Synopsis
- Acute myeloid leukemia (AML) with the t(7;12) translocation is common in infants and has been recognized by the WHO, although the exact mechanism behind its development is unclear.
- A study of 12 pediatric AML cases with this translocation found no significant difference in survival rates compared to other AML types, but noted a consistent high expression of MNX1 across all cases.
- Whole transcriptome and genome sequencing revealed various fusion transcripts, primarily involving NOM1, but emphasized the importance of MNX1's overexpression as the key driving factor in this AML subtype.