CDK4 selective inhibition improves preclinical anti-tumor efficacy and safety.

CDK4/6 inhibitors have revolutionized treatment of hormone receptor positive (HR+), HER2 non-amplified (HER2-) breast cancer. Yet, all "dual" CDK4/6 inhibitors show common dose-limiting hematologic toxicities, foremost neutropenia. This poses challenges to provide these agents at concentrations necessary to extinguish cell cycling in tumors.

My Life: A Photovoice Exploration of Aspirations of People With Intellectual Disabilities.

Background: This study aimed to evaluate the everyday ways that individuals with mild and moderate intellectual disabilities exercise choice and control.

Method: Photovoice with 17 adults with mild to moderate intellectual disability who were receiving individual funding was conducted. Focus groups were held to review the photos.

Clinical utility and safety of finerenone in patients with heart failure: Rationale and design of FINE registry.

Aims: Information about current use of finerenone in patients with heart failure (HF) finerenone in clinical practice is scarce, and its effectiveness in clinical practice in patients is scarce. We aim to assess both the baseline clinical profile and prognostic role of finerenone in patients with HF, irrespective of ejection fraction.

Methods And Results: The study is a multicentre, observational registry, including regional and tertiary hospitals.

Educating the educated: The impact of educational interventions on knowledge, attitudes and confidence of healthcare professionals in caring for patients with intellectual disability: A systematic review.

Background: The attitudes, perceptions and inherent biases of healthcare professionals (HCPs) have the potential to influence and inform health outcomes of people with intellectual disability. This review aimed to identify what educational interventions have been conducted to improve the attitude, knowledge, and confidence of HCPs in caring for people with intellectual disability.

Method: A systematic literature review was conducted using Medline, ERIC and PsycINFO.

Methodology for the correction of a CBCT volume from the skull to the natural head position.

The orientation of the head during the acquisition of cone beam computed tomography (CBCT) is crucial for accurate cephalometric measurements. However, involuntary head movements during the scan can result in misaligned images. This study presents a method to correct the natural head position (NHP) in CBCT skull images after acquisition.