Publications by authors named "G J Fowler"

Article Synopsis
  • - PARP inhibitors show promise in treating castration-resistant prostate cancer (CRPC) with homologous recombination repair (HRR) defects, but the reasons behind resistance are not completely understood.
  • - A study from the TOPARP-B trial found that 79% of BRCA2/PALB2-mutated tumors exhibited reversion mutations at the end of treatment, with many related to POLQ-mediated DNA repair mechanisms.
  • - In cases of BRCA2 homozygous deletions, rare subclones lacking the BRCA2 deletion are selected for after PARP inhibitor treatment, indicating the necessity for restored HRR function in developing resistance.
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Integrated circuits (ICs) and central processing units (CPUs), essential components of electrical and electronic equipment (EEE), are complex composite materials rich in recyclable high-value strategic and critical metals, with many in concentrations higher than in their natural ores. With gold the most valuable metal present, increase in demand for gold for EEE and its limited availability have led to a steep rise in the market price of gold, making gold recycling a high priority to meet demand. To overcome the limitations associated with conventional technologies for recycling e-waste, the use of greener technologies (ionic liquids (ILs) as leaching agents), offers greater potential for the recovery of gold from e-waste components.

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DNA sensing is important for antiviral immunity. The DNA sensor cGAS synthesizes 2'3'-cyclic GMP-AMP (cGAMP), a second messenger that activates STING, which induces innate immunity. cGAMP not only activates STING in the cell where it is produced but cGAMP also transfers to other cells.

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Background: Subungual melanoma (SUM) is a rare tumor with historically poor outcomes. Thus, the benefit of proximal versus distal amputation in SUM remains unclear.

Methods: We performed a retrospective review of our prospectively-maintained institutional melanoma database, including SUM and non-subungual acral melanoma (AM) patients who underwent sentinel lymph node biopsy (SLNB) between 1999 and 2022.

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Objective: To examine the postnatal psychological health and parenting adjustment of primiparous women experiencing perineal trauma.

Study Design: Longitudinal cohort study assessing body image, perceptions of traumatic birth, psychological distress, perineal pain, impact upon parental tasks and mother-infant bonding at 6-12 weeks (n = 103) and 6-10 months postnatally (n = 91). Primiparous women were recruited following vaginal birth and perineal suturing in a UK-based maternity hospital.

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