Autologous intervertebral disc cell implantation: a model using Psammomys obesus, the sand rat.

Study Design: Work presented here used a small animal model to illustrate the feasibility of autologous disc cell implantation.

Objectives: To develop a small animal model for autologous disc cell implantation.

Summary Of The Background Data: The use of autologous disc cells in the potential treatment of disc degeneration offers attractive possibilities for novel therapies.

Effects of very high antibiotic concentrations on human intervertebral disc cell proliferation, viability, and metabolism in vitro.

Study Design: Four antibiotics commonly used during spinal surgery (cefazolin, gentamycin, cefamandole, and vancomycin) were tested for their effects on cultured human disc cells from the anulus.

Objective: To determine the viability, proliferation, and metabolism of cells cultured from the human anulus after they were exposed to four antibiotics.

Summary Of Background Data: Previous studies concerning the effect of antibiotics on the disc have used animal models or explanted discs, but little is understood about the effect of antibiotics on the proliferation, viability, and metabolism of cells from the anulus.

Three-dimensional polyethylene wear of a press-fit titanium prosthesis. Factors influencing generation of polyethylene debris.

Between 1985 and 1990, 108 consecutive Harris-Galante I (Zimmer, Warsaw, IN) total hip arthroplasties were performed by four surgeons at a single hospital. At the time of follow-up evaluation, 80 hips were available for review. The mean rate of linear wear was 0.

Antibiotic protocol for appendicectomy--costs and benefits of single dose therapy.

Aims: To examine possible savings from the introduction of an antibiotic protocol for one surgical procedure and to define antibiotic charting techniques.

Methods: An antibiotic policy for patients undergoing an appendicectomy was instituted in the surgical unit at North Shore Hospital to examine possible savings and to define antibiotic charting techniques. Depending on the macroscopic findings at surgery a third generation cephalosporin was used either as a single dose intraoperatively or for multiple doses postoperatively.