A simplified multidimensional scale approach is effective in predicting mortality in hospitalized older adults and highlights the role of nutrition.

Background & Aims: Malnutrition and cognitive impairment are among the major contributors to frailty, that significantly increases the risk of mortality of older hospitalized patients. Multidimensional frailty assessment tools, such as the multidimensional prognostic index-MPI, a tool based on a standard comprehensive geriatric assessment (CGA), have proven valuable for predicting adverse outcomes, including mortality of older adults following acute illness but its application in everyday clinical practice is limited. We hypothesized that removing parameters not closely associated with mortality and sorting the patient population according to the presence or not of cognitive impairment with possible integration of common laboratory markers, could provide a simplified approach that could improve practicability in all settings with at least comparable 1-year mortality predictive value.

[Information, knowledge, and perception of dengue risk in Argentina: two intervention experiments to generate local control strategies].

With the objectives of dengue prevention, health promotion, and action-based research, two experiments were conducted in pilot areas of Buenos Aires and Vicente López, Argentina. In each area, community, government, and non-governmental references were identified. The study included an entomological survey (with ovitraps), environmental survey (with field observations, interviews, and workshops), and social survey (using questionnaires, interviews, and meetings).

Coexistence of two different intraspinal tumors. Case report and review of the literature.

The occurrence of multiple neoplasms in the central nervous system is well documented. In von Recklinghausen's disease, patients frequently present with multiple neurofibromas and/or meningiomas at different sites within the spinal axis. However, the presence of multiple, histologically different spinal tumors in the absence of von Recklinghausen's disease is extremely rare.

Anterior cervical discectomy and fusion with implantable titanium cage: initial impressions, patient outcomes and comparison to fusion with allograft.

Background Context: The use of metal cage prosthetic devices in anterior cervical discectomy with fusion (ACDF) has increased rapidly. One of these devices is the titanium Rabea cage (Signus, Alzenau, Germany) [correction]. There are no peer-reviewed objective reports on the use of these cages in cervical discectomy.

Tandem duplication of the epidermal growth factor receptor tyrosine kinase and calcium internalization domains in A-172 glioma cells.

Amplification and rearrangement of the epidermal growth factor receptor (EGFR) gene occur frequently in malignant gliomas. Rearrangement may also lead to the expression of potentially oncogenic EGFR deletion mutants. Data presented here indicate the existence of a 190 kDa mutant form of the EGFR in A-172 glioma cells that is substantially different from the deletion mutants characterized previously.