Publications by authors named "G J Behets"
Serum calcium isotopes (δCa) have been suggested as a non-invasive and sensitive Ca balance marker. Quantitative δCa changes associated with Ca flux across body compartment barriers relative to the dietary Ca and the correlation of δCa with bone histology are unknown. We analyzed Ca and δCa by mass-spectrometry in rats after two weeks of standard-Ca-diet (0.
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- - This study investigates how kidney transplantation affects bone health over the first year after the procedure, focusing on various bone metrics before and after transplantation using steroid-sparing immunosuppressive protocols.
- - Data from 97 patients (average age 55, mostly male) showed that bone turnover improved or remained normal for most, with significant reductions in bone resorption and fibrosis, though some experienced delayed mineralization and variable changes in bone density.
- - Results indicate that factors like steroid doses and mineral metabolism play crucial roles in bone health post-transplant, suggesting that better management of these aspects could enhance bone quality in kidney transplant patients.
Rationale & Objective: Bone biopsy remains the gold standard for diagnosing renal osteodystrophy as comparable noninvasive alternatives have yet to be established. This study investigated the diagnostic accuracy of biochemical markers of skeletal remodeling to predict bone turnover.
Study Design: Cross-sectional retrospective diagnostic test study.
Patterns of renal osteodystrophy 1 year after kidney transplantation.
Nephrol Dial Transplant
November 2021
Background: Renal osteodystrophy is considered common, but is not well characterized in contemporary kidney transplant recipients. This study reports extensively on bone phenotype by bone histomorphometry, bone densitometry and novel bone biomarkers 1 year after kidney transplantation.
Methods: A transiliac bone biopsy and dual-energy X-ray absorptiometry scans were performed in 141 unselected kidney transplant recipients in this observational cohort study.
A bone biopsy with prior tetracycline labeling is the gold standard to diagnose renal osteodystrophy. In cases of missing tetracycline labels, it is still paramount to gain clinically relevant information from the extracted bone sample, by evaluating the static histomorphometry. This study investigates the diagnostic performance of static histomorphometry for the evaluation of high and low bone turnover.
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