Publications by authors named "G J Bansal"
Article Synopsis
- The study investigates the relationship between Bispectral Index (BIS) and age-adjusted Minimum Alveolar Concentration (aaMAC) during anesthesia maintenance in adults.
- Factors such as age, ASA status, and specific anesthetic agents were found to influence BIS readings, indicating that older patients and those given certain drugs showed higher BIS at the same aaMAC.
- A generalized estimation equation was developed to predict either BIS or aaMAC based on known values, despite significant variances in their relationship.
Interleukin-6 (IL-6) is a pleiotropic cytokine that plays a major role in the development of Rheumatoid Arthritis (RA). In the present study, benzimidazole and benzene sulfonyl scaffold were identified as pharmacophore by analysis of literature reports and novel small molecule IL-6 inhibitors were designed. These were screened via docking with IL-6 (PDB: 1ALU), then and through Lipinski's rule of 5.
View Article and Find Full Text PDFVascular endothelial growth factors (VEGFs) are a class of homodimeric ligands that bind to their receptors (VEGFRs) to carryout physiological and pathological angiogenesis essential for regulating homeostasis of body. Overexpression of VEGF results in metastasis of benign tumor into malignant tumor. An active role of VEGFR-2 in cancer angiogenesis makes it a major target for cancer therapy.
View Article and Find Full Text PDFArticle Synopsis
- Bacterial gastrointestinal diseases, particularly those caused by various Shigella species, lead to significant health issues globally, causing approximately 125 million cases of shigellosis and 14,000 deaths each year, mostly in young children in developing nations.
- A Phase 1 clinical trial evaluated the safety and tolerability of a new treatment called ShigActive™, a lytic bacteriophage aimed at Shigella, comparing its effects with a placebo over 29 days.
- Results showed that ShigActive™ was generally safe and well tolerated, with mild side effects reported by some participants and no serious adverse events, indicating it could be a potential option for treating shigellosis
Article Synopsis
- The text discusses a diverse species that infects both humans and animals, specifically focusing on non-typhoidal serovars (NTS) that cause foodborne illnesses and can lead to economic losses in livestock.
- It highlights recent advancements in genetic engineering that have facilitated the development of vaccines for both humans and animals.
- The review covers various types of vaccines, including recombinant live-attenuated vaccines, parenteral vaccines, and live-vector vaccines, with applications for both human and animal health.