Publications by authors named "G J Amabeoku"
Antinociceptive, anti-inflammatory and antipyretic activities of the leaf methanol extract of Ruta graveolens L. (Rutaceae) in mice and rats.
Afr J Tradit Complement Altern Med
July 2015
Background: Ruta graveolens has been used to treat toothache, earache, rheumatism and fever with little scientific evidence corroborating these uses.
Materials And Methods: The leaf methanol extract of Ruta graveolens was evaluated for antinociceptive activity using the acetic acid writhing and hot-plate tests in mice, also anti-inflammatory and antipyretic activities using the carrageenan-induced oedema and E. coli-induced pyrexia tests in rats, respectively.
Article Synopsis
- The leaf methanol extract of C. orbiculata L. was tested on mice and rats for its ability to reduce pain and inflammation through several experiments, including acetic acid writhing and hot-plate tests.
- The results showed that the extract significantly reduced pain responses and inflammation in both tests, comparable to known painkillers like paracetamol and morphine.
- Additionally, the high LD(50) value (greater than 4000 mg/kg) indicates that C. orbiculata is likely safe and non-toxic for these animals, supporting its traditional medicinal use for pain and inflammation relief.
Antipyretic and antinociceptive properties of Mentha longifolia Huds. (Lamiaceae) leaf aqueous extract in rats and mice.
Methods Find Exp Clin Pharmacol
December 2009
Article Synopsis
- The study examined the effects of Mentha longifolia leaf aqueous extract on reducing fever (pyrexia) and pain (antinociceptive properties) using experiments on rats and mice.
- The extract significantly lowered LPS-induced fever in rats and inhibited pain responses in mice, comparable to standard drugs like pentoxifylline, paracetamol, and morphine.
- Phytochemical analysis indicated that the leaves contain beneficial compounds, and the extract was found to be non-toxic at high doses, suggesting its potential use in medicine for fever and pain relief.
Ethnopharmacological Relevance: Geranium incanum Burm. f. (Geraniaceae) is used in South Africa especially in rural communities by traditional medicine practitioners to treat diarrhoea.
View Article and Find Full Text PDF