The incidence of snakebite in South Africa and the challenges associated with lack of reporting.

Background: Snakebite is a public health challenge that has a substantial impact on humans and snakes. Annually, millions of people are affected by snakebite globally but there is a paucity of detailed data on snakebite incidences. The aim of this study was to assess the patterns of snakebite incidences in South Africa.

Use of Statins for Primary Prevention Among Individuals with CKD in the United States: A Cross-Sectional, Time-Trend Analysis.

Rationale & Objective: Chronic kidney disease (CKD) populations face an elevated risk of cardiovascular disease (CVD), yet many remain undertreated with statins for primary prevention of CVD despite meeting eligibility criteria. We examined trends in statin use for primary prevention among individuals with CKD before and after the release of the 2013 Kidney Disease: Improving Global Outcomes (KDIGO) guideline recommending statin use for lipid management in selected adults with CKD.

Study Design: Cross-sectional time-trend analysis.

Perineuronal nets on CA2 pyramidal cells and parvalbumin-expressing cells differentially regulate hippocampal dependent memory.

Perineuronal nets (PNNs) are a specialized extracellular matrix that surround certain populations of neurons, including (inhibitory) parvalbumin (PV) expressing-interneurons throughout the brain and (excitatory) CA2 pyramidal neurons in hippocampus. PNNs are thought to regulate synaptic plasticity by stabilizing synapses and as such, could regulate learning and memory. Most often, PNN functions are queried using enzymatic degradation with chondroitinase, but that approach does not differentiate PNNs on CA2 neurons from those on adjacent PV cells.

Understanding Daily Care Experience Preferences Across the Lifespan of Older Adults: Application of Natural Language Processing.

Introduction: Older adults are a heterogeneous group, and their care experience preferences are likely to be diverse and individualized. Thus, the aim of this study was to identify categories of older adults' care experience preferences and to examine similarities and differences across different age groups.

Methods: The initial categories of older adults' care experience preferences were identified through a qualitative review of narrative text (n = 3134) in the ADVault data set.

An audit of the impact of the introduction of a commercial artificial intelligence driven auto-contouring tool into a radiotherapy department.

Objectives: To audit prospectively the accuracy, time saving and utility of a commercial artificial intelligence auto-contouring tool (AIAC). To assess the reallocation of time released by AIAC.

Methods: We audited the perceived usefulness (PU), clinical acceptability and reallocation of time during the introduction of a commercial AIAC.