Publications by authors named "G Iu Popova"
Dirofilariasis is a zoonotic infection that humans acquire by the bite of infected mosquitoes. The male reproductive system is relatively rare affected by this disease. We presented a case of dirofilariasis of the scrotum from Bulgaria.
View Article and Find Full Text PDFHomogeneous antibody-drug conjugates (ADCs) exhibit significantly improved pharmacological properties compared to their heterogeneous counterparts. Site-specific conjugation of the payload to the IgG required for homogeneity can be achieved using enzymes. One example is microbial transglutaminase (MTGase), which can selectively perform transamidation on the Q295 residue of human Fc when N297 glycans are removed.
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- Nervous system cancers show different cell states influenced by various factors, but understanding their regulation and potential treatments is still lacking.
- The "single-cell regulatory-driven clustering" (scregclust) method analyzes single-cell RNA sequencing data to identify key regulatory programs in brain tumors and developing tissues, efficiently predicting important transcription factors and kinases.
- Using this method, critical regulators were found that might enhance temozolomide treatment for glioblastoma, and its flexibility was proven by applying it to different tumor types, making it accessible as a user-friendly R package for further research.
We report a case of infection with the zoonotic nematode sp. in a 24-year-old woman from Varna, Bulgaria. Two days before seeking medical attention, the patient had noticed a filamentous mass in her buccal mucosa that migrated when touched with the tongue.
View Article and Find Full Text PDFMultiplex PCR in Diagnosing Respiratory Tract Infections in Hospitalized Children.
Pril (Makedon Akad Nauk Umet Odd Med Nauki)
March 2024
Objectives: To elaborate the utility of multiplex quantitative polymerase chain reaction (multiplex qPCR) for the accurate diagnosis of severe respiratory tract infections (RTIs) in hospitalized children.
Methods: In two separate periods during 2022, 76 respiratory specimens (combined throat/nasopharyngeal swabs) were submitted for multiplex qPCR regarding 26 respiratory pathogens. The specimens were obtained from children with severe RTIs hospitalized in the Institute for Respiratory Diseases in Children, Skopje.