[The evolution of psychiatric troubles in patients suffering from primary hypogonadism treated by a testicular transplant].

Observation of a group of 60 patients affected by a primary hypogonadism and followed before and after a testicular transplant. They were separated into three sub-groups and the final evaluation was established according to the differences of each sub-group.

[Specific bradycardic drug zatebradin: cardiac rhythm variability, antifibrillatory, and antiischemic effects].

The results of experiments on narcotized cats and rats showed that the drug zatebradin produces a specific bradycardic action by reducing the heart rate and the double product, while virtually not influencing vitally important parameters of the heart activity such as the cardiac output and the mean acceleration of the aorta blood flow. The drug reduced the rise of ST segment recorded in multiple epicardial ECG leads made in narcotized cats during a 5-min occlusion of the anterior descending branch of the left coronary artery. Zatebradin was found to increase the cardiac rhythm variability in narcotized rats and decrease the rate of ventricular fibrillations during a 7-min occlusion with the subsequent 3-min coronary artery reperfusion.

[Activation of the sympathetic nervous system influences the antifibrillatory effect of class I antiarrhythmic drugs].

The experiments with anesthetized rats showed that drugs belonging to various subclasses of class I antiarrhytmic agents (novocainamide, IA; lidocaine, IB; ethacizine, IC) produce a pronounced antifibrillatory and antiarrhythmic action under the conditions of a 7-min occlusion followed by reperfusion of the anterior descending branch of the left coronary artery. In the arrhythmia model with beta-adrenoreceptors stimulated by isoproterenol, novocainamide (IA) and lidocaine (IB) retained their efficacy, in contrast to ethacizine (IC). This difference in the behavior of antiarrhythmic drugs may be related to their different antiarrhythmogenic potentials.

[Effect of the sympathetic nervous system activation on the antifibrillatory efficacy of various anti-arrhythmia agents].

Experiments with a 7-min occlusion followed by reperfusion of the left coronary artery in narcotized rats showed that antiarrhythmic drugs of various classes--ethacizin (class I), AL-275 (class III), and CM-345 (class V)--produce pronounced antifibrillatory and antiarrhythmic effects. AL-275 and CM-345, in contrast to ethacizin, retained their efficacy under the conditions of isoproterenol-induced stimulation of beta-adrenoceptors. This difference in behavior is probably explained by dissimilar effects of the antiarrhythmics on the ion channels of cardiomyocite membranes.

[Pharmacodynamics and pharmacokinetics of the new specific bradycardic preparation bradizole].

The new drug Bradizol (SM-345), a 2-mercaptobenzimidazole derivative producing a specific bradycardic effect, is quite rapidly eliminated upon intravenous bolus in anaesthetiezed cats. After a combined injection (bolus followed by a 60-min infusion), a constant bradizol concentration in the blood plasma is observed over a time period of 90 min. The bradizol-induced bradycardic effect and the drug concentration in the blood plasma are tightly correlated.