Publications by authors named "G Itzikowitz"

Background: Growing evidence indicates that gender-based violence (GBV) increased during COVID-19. We investigated self-reported impact of the pandemic on GBV at community, household and intimate partner (IPV) levels among young people and its associations with psychosocial wellbeing, i.e.

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Objective: To examine sexual and reproductive health (SRH) service access among South African young people during the COVID-19 pandemic.

Study Design: We utilized cross-sectional data collected from February to October 2021 in Cape Town among young people 13-24 years of age living with and without HIV.

Results: Two hundred and fifteen young people living with HIV (YPLWH) and 320 young people living without HIV were included.

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Article Synopsis
  • This study investigates the role of high-impact genetic variants in over a thousand genes linked to Mendelian neurodevelopmental disorders (NDD) by characterizing 28 probands with de novo heterozygous coding variants.
  • Among the identified variants, 15 unique changes were found, including missense, in-frame deletions, and a splice variant, affecting the Argonaute 1 protein involved in gene-silencing pathways, which suggests these mutations may disrupt mRNA processing.
  • The affected individuals exhibited a range of symptoms, such as intellectual disabilities, speech and motor delays, and autistic behaviors, highlighting the potential significance of these genetic variants in understanding NDD.
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Background: Pneumonia remains a major cause of morbidity and mortality amongst South African children. More comprehensive immunisation regimens, strengthening of HIV programmes, improvement in socioeconomic conditions and new preventive strategies have impacted on the epidemiology of pneumonia. Furthermore, sensitive diagnostic tests and better sampling methods in young children improve aetiological diagnosis.

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