CIC/ATXN1-rearranged tumors in the central nervous system are mainly represented by sarcomas: A comprehensive clinicopathological and epigenetic series.

CIC fusions have been described in two different central nervous system (CNS) tumor entities. On one hand, fusions of CIC or ATXN1 genes belonging to the same complex of transcriptional repressors, were reported in the CIC-rearranged, sarcoma (SARC-CIC). The diagnosis of this tumor type, which was recently added to the World Health Organization (WHO) Classification of CNS tumors, is difficult mainly because the data concerning its histopathology (as compared to its soft tissue counterpart), immunoprofile, and clinical as well as radiological characteristics are scarce in the literature.

Security and reliability of CUSTOMBONE cranioplasties: A prospective multicentric study.

Background: Repairing bone defects generated by craniectomy is a major therapeutic challenge in terms of bone consolidation as well as functional and cognitive recovery. Furthermore, these surgical procedures are often grafted with complications such as infections, breaches, displacements and rejections leading to failure and thus explantation of the prosthesis.

Objective: To evaluate cumulative explantation and infection rates following the implantation of a tailored cranioplasty CUSTOMBONE prosthesis made of porous hydroxyapatite.

Is More Always Better?: Discovering Incentivized mHealth Intervention Engagement Related to Health Behavior Trends.

Behavioral medicine is devoting increasing attention to the topic of participant engagement and its role in effective mobile health (mHealth) behavioral interventions. Several definitions of the term "engagement" have been proposed and discussed, especially in the context of digital health behavioral interventions. We consider that engagement refers to specific interaction and use patterns with the mHealth tools such as smartphone applications for intervention, whereas adherence refers to compliance with the directives of the health intervention, independent of the mHealth tools.

wrapper: Operationalizing engagement strategies in mHealth.

The advancement of digital technologies particularly in the domain of mobile health (mHealth) holds great promise in the promotion of health behavior. However, keeping users engaged remains a central challenge. This paper proposes a novel approach to address this issue by supplementing existing and future mHealth applications with an engagement wrapper - a collection of engagement strategies integrated into a single, coherent model.