Publications by authors named "G Iaccarino"
In patients with type II diabetes, the development of diabetic cardiomyopathy (DC) is associated with a high risk of mortality. Left ventricular hypertrophy, diastolic dysfunction, and exercise intolerance are the first signs of DC. The underlying mechanisms are not fully elucidated, and there is an urgent need for specific biomarkers and molecular targets for early diagnosis and treatment.
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- * In the study, 689 participants were categorized into three groups based on migraine resistance, with significant differences in the number and type of comorbidities found among them.
- * The findings suggest that higher comorbidity rates may contribute to the worsening of migraines, potentially making them harder to treat over time.
Background: Arterial dissection, a condition marked by the tearing of the carotid artery's inner layers, can result in varied clinical outcomes, including progression, stability, or spontaneous regression. Understanding these outcomes' underlying mechanisms is crucial for enhancing patient care, particularly with the increasing use of computer simulations in medical diagnostics and treatment planning. The aim of this study is to utilize computational analysis of blood flow and vascular wall to: (1) understand the pathophysiology of stroke-like episodes in patients with carotid artery dissection; and (2) assess the effectiveness of this method in predicting the evolution of carotid dissection.
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- Alzheimer's disease is linked to abnormal deposits of beta-amyloid and tau proteins, and blood biomarkers may help detect them; decreased kidney function could impact how these biomarkers are cleared from the body.
- This study analyzed the relationship between kidney function, blood biomarker levels, and cognitive impairment in Alzheimer’s patients without chronic kidney disease, using retrospective data and blood samples to measure various protein levels.
- Results showed that only plasma levels of Aβ42 were significantly affected by kidney function, suggesting that renal function influences the clearance of this particular protein, while other Alzheimer's biomarkers remained unaffected.
Background: In high-risk breast cancer patients with skin infiltration, the administration of a uniform dose to superficial tissues is fundamental in order to reduce local skin relapse. A personalized bolus may prevent the potential inadequate dose distribution of a standard bolus due to air gaps between the bolus and the skin. In this pilot study, we introduced into clinical practice the use of a personalized 3D-printed bolus filled with ultrasound transmission gel.
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