[Influence of the brain functional state evoked by spreading depression wave propagation on the recurrent waves properties].

EEG aftereffects of spreading depression waves were studied in waking rabbits in chronic experiments by spectral coherence analysis. Experiments were divided in two groups: early (from the first to the third-fourth experiments) and late (fifth-tenth experiments). During the early experimental series, unilateral persistent EEG changes consisting in an increase in the delta- and beta-band power with a simultaneous depression of the gamma-band activity were observed in the ipsilateral to SD hemisphere.

[Changes in the high-frequency electrical brain activity in the animal hypnosis state in rabbits].

The EEG spectral analysis applied to electrical brain activity of rabbits in the state of animal hypnosis revealed a 2-4-fold increase in the power of the sigma frequency band (12-17 Hz) and a 1.5-2-fold decrease in the gamma frequency (especially 40-70 Hz) in addition to well-known growth of delta (0.3-3 Hz) and reduction of theta activity (4-8 Hz).

Properties of spreading depression identified by EEG spectral analysis in conscious rabbits.

Reflection of cortical waves of spreading depression in changes in high-frequency gamma activity was shown to improve significantly in conditions of bipolar recording of brain electrical activity. Intense suppression of the EEG gamma range (37-47 Hz) was seen in all cortical areas studied at the moment of onset of waves of spreading depression. The drop in the power of EEG gamma activity had clear leading and trailing fronts, allowing the passage time of the wave to be evaluated in each cortical area, as well as the sequence of propagation.

[Spreading depression in a waking rabbit with the spectral EEG analysis].

It was shown that the manifestation of the SD phenomenon in dynamics of the cortical high-frequency gamma activity is rather prominent after bipolar interpretation of the common reference electrode derivations, i.e. when the modeling of the bipolar signal on the base of monopolar EEG recordings is used.

Suppression of EEG gamma activity--an informative measure of spreading depression waves in the neocortex of the conscious rabbit.

Spreading depression can arise spontaneously in convulsions, migraine attacks, vascular lesions, and other pathological brain states. However, the methodological complexity of recording a direct current potential in the neocortex in humans and conscious animals significantly limits studies of the functional consequences of spreading depression. The present report describes a detailed analysis of the EEG dynamics at the moment of development of spreading depression waves and identifies specific signs allowing spreading depression to be recorded without recording changes in the direct current potential.