[The possibilities of early diagnosis of tumorous lesions of colon patency and their preoperative correction].

Experiments in white rats were used in order 1) to create a model of obturative colon obstruction (OCO) and to prove a staged character of its development depending on the tone of the Bauhin's valve (the normotonic phase, spasm of the Bauhin's valve, dilatation of the Bauhin's valve) and 2) to study specific features of healing primary anastomoses after emergency resections of the colon. An analysis of clinical and rentgenological findings has confirmed the staged character of tumor lesions of the colon patency (TLCP). A working classification of them is proposed: stages of compensation (conventionally chronic); subcompensation (subacute) with three degrees of stages according to the experimental scheme of pathogenesis; decompensated (acute obturative colon obstruction).

[Microcirculatory changes in patients with hypertensive disease caused by excessively lowered blood pressure after clofelin administration].

In 20 patients with Stage II hypertensive disease, erythrocyte and platelet aggregation to response to ATP was photooptically studied, skin oxygen tension was polarographically examined, and the diameters of conjunctival vessels were microscopically measured. In the patients, excessive decreases in blood pressure were found to lead to lack of microvascular tone coordination, to increases in platelet and erythrocyte aggregation and to decreases in tissue oxygen supply. It was emphasized that the microcirculation and tissue oxygen supply should be monitored when clofelin dosages are chosen individually in the treatment of hypertensive disease.

[2-Deoxyglucose as a tool for analyzing the humoral component of the cardiovascular reaction to stress].

Blood pressure (BP), heart rate (HR), adrenaline (A) and noradrenaline (NA) effects of 2-desoxyglucose (500 mg/kg i.v.) were studied in conscious chronically instrumented wistar rats.

[Blood flow in skin wound tissue and systemic hemodynamics as affected by a collagen-dalargin complex].

In has been demonstrated that a collagen-dalargin complex increases blood flow in the granulation tissue (microsphere technique) due to the formation of new capillaries and a decrease in the vascular resistance. Dalargin had no effect on the capillary blood flow in the unaffected tissues. It has been concluded that the wound healing effect of dalargin may be related to its involvement in angiogenesis regulation.