[Pathophysiologic mechanisms of psychopathologic phenomena and psychopharmacotherapy].

The paper is concerned with the questions of genesis of psychopathological symptomatics in terms of the theory of Academician G. N. Kryzhanovsky of determinant structures and generator activity.

[Electroconvulsive therapy of trigeminal neuralgia].

The authors describe a new method of the treatment of patients with trigeminal neuralgias using electroconvulsive therapy. The method is based on the increase of beta-endorphin concentration as a result of electroconvulsive treatment. The treatment of 12 patients in accordance with the suggested method provided beneficial results and significant enhancement of the efficacy of therapy as compared to patients undergoing conventional treatment.

[Treatment of attack-like forms of schizophrenia in patients with residual cerebral organic insufficiency].

As a result of studying 727 therapy courses conducted in 90 patients with attack-like schizophrenia, who suffered 294 attacks, it has been demonstrated that in case these patients have residual organocerebral failure, a special choice of "sparing" therapy is required. The treatment of these patients consists in the use of neuroleptics which do not provoke any marked extrapyramidal side effects (sonapax, eglonyl, leponex), tranquilzers and antidepressants possessing no cholinolytic effect (pyrazidol, nuredal). If the use of powerful antipsychotic neuroleptics and tricyclic antidepressants is required, it is indicated that they can be applied in the form of intravenous infusions.

[Effect of prior psychopharmacotherapy on the development, clinical course and therapeutic effect of insulin coma in patients with schizophrenia].

In 123 patients the peculiarities of formation and effectiveness of insulin coma (IC) were studied under drug therapy as compared with 49 drug-free patients. Pharmacotherapy preceding the ICs produced uneven effect on its course. Artefact course of IC was most frequently observed after mageptil, chlorpromazine melipramine treatment, and to a lesser extent--after haloperidol, triphtazin, amitriptyline.