[Effect of carbostimulin on metabolism in rats with deep burns].

It is established that at early stages of the burn disease (deep burn of III-B degree, 20% of body surface) in rats there appears metabolic acidosis, the content of urea increases in the liver and blood serum, a pronounced hydration of the liver and muscles is observed in the burn zone. Administration per os of carbostimulin just a day after burn removes symptoms of metabolic acidosis. When the preparation is fed to rats during 7 days after burn the intensity of radioactive label incorporation into proteins, lipid and glycogen of the liver as well as in proteins and lipids of kidneys and spleen increases.

[Treatment of anemia in pregnant women by a complex method with application of carbostimulin].

The medicinal effect of carbostimulin was studied under conditions of anemia in pregnant women. A group of pregnant women (n-54) who were given carbostimulin in addition to the ordinary antianemic therapy showed a 2.5-fold increase of erythrocytes and 1.

[New data on carbonic acid fixation in animals and man].

Recently a new enzymic carboxylation reaction has been discovered at the final-step of prothrombin and other proteins synthesis. The presence of the unique amino acid, gamma-carboxyglutaminic acid, is established and its structure is determined. The role of the acid is shown in Ca2+ fixation in the known proteins, playing an important role in the blood coagulation processes, and in some new proteins participating in the tissue calcification.

[Dependence of the 14C label determination efficiency in proteins under certain experimental conditions].

A simple, economical, highly productive and easily reproducible method is suggested for making 14C-labelled preparations of denaturated proteins to determine their radioactivity by the liquid scintillation counter. The advantages of the methods are as follows: it is possible for a short period of time to make a large number of preparations; the counted vessels are not contaminated during the work; scintillation liquid consumption is considerably reduced.

[Effect of carboxylation reactions stimulation on intensity of 14CO2 fixation in rabbits with posthemorrhage anemia and on repairing of blood components in human anemia].

The repair processes with posthemorrhage anemia were studied in experiment and clinics as affected by the preparation (sodium bicarbonate and magnesium, manganese and zinc sulphates in a ratio of 25:5:0.1:0.1) which stimulates the carboxylation reactions in the organism.