Publications by authors named "G I Wolfe"
Article Synopsis
- The management of generalized myasthenia gravis (gMG) has seen significant advancements in pharmacological treatments over the last 7 years, with new drugs available for patient care.
- Recent developments include complement inhibitors and neonatal Fc receptor antagonists, which have completed successful Phase 3 studies and are now on the market in many countries.
- Long-term studies show these agents are effective, with benefits like reducing the need for corticosteroids, prompting discussions about current and future applications in gMG treatment.
Article Synopsis
- Wildfires are a growing contributor to air pollution, particularly due to reactive organic compounds (ROC), which have varying health impacts based on their toxicity and abundance.
- A study combining field campaign data and air quality modeling found that current emissions estimates capture only 40-45% of the total ROC released from wildfires.
- The research indicates that particulate ROC could significantly affect health risks from smoke exposure, highlighting the need for more accurate toxicity data on these compounds.
Article Synopsis
- * Most MG patients have acetylcholine receptor antibodies, but other notable antibodies like MuSK and LRP4 have also been identified, with some being available for testing.
- * The Myasthenia Gravis Foundation of America (MGFA) has established a disease classification system, and a range of therapies for managing MG are being researched and developed, guided by international recommendations.
The Bacillus Calmette-Guérin (BCG) vaccine, which has been used for > 100 years to prevent tuberculosis, is well-established for bladder cancer treatment, and under study for neurological and autoimmune diseases. In patients with type 1 diabetes (T1D), BCG vaccinations have been shown in randomized clinical trials to gradually lower blood sugar to near normal levels. This effect appears to be driven by a BCG-induced shift in lymphoid cells' glucose metabolism from oxidative phosphorylation to aerobic glycolysis.
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