HIV-1 Drug Resistance among Treatment-Naïve Patients in Russia: Analysis of the National Database, 2006-2022.

In Russia, antiretroviral therapy (ART) coverage has significantly increased, which, in the absence of routine genotyping testing, could lead to an increase in HIV drug resistance (DR). The aim of this study was to investigate the patterns and temporal trends in HIV DR as well as the prevalence of genetic variants in treatment-naïve patients from 2006 to 2022, using data from the Russian database (4481 protease and reverse transcriptase and 844 integrase gene sequences). HIV genetic variants, and DR and DR mutations (DRMs) were determined using the Stanford Database.

[Molecular epidemiological analysis of HIV-1 variants circulating in Russia in 1987-2015].

Aim: To simultaneously analyze HIV-1 samples from all Russian regions to characterize the epidemiology of HIV infection in the country as a whole.

Subjects And Methods: The most extensive study was conducted to examine nucleotide sequences of the pol gene of HIV-1 samples isolated from HIV-positive persons in different regions of Russia, with the diagnosis date being fixed during 1987-2015. The nucleotide sequences of the HIV-1 genome were analyzed using computer programs and on-line applications to identify a virus subtype and new recombinant forms.

[Investigation of genetic polymorphism of the integrase gene in the HIV-1 subtype A populations circulating in the Russian Federation].

The paper presents the data of an investigation of the genetic polymorphism of the pol gene encoding viral integrase (IN) in a HIV subtype A infected population in the Lipetsk Region. The investigators analyzed 32 virus subtype A samples obtained in 2002-2007. Polymorphism at the codons associated with IN resistance to chemicals was observed in 7 virus variants.

[Molecular epidemiologic characteristics of HIV-1 variants isolated in the Lipetsk region].

Molecular epidemiologic study of HIV-1 variants isolated in the Lipetsk region during 1994 - 2006 period was performed. It has been shown that 3 env-subtypes (A, B, and C) and 3 gag-subtypes (A, B, and C) are widespread in the region. The virus was transmitted both sexually and by injecting drug users.

[Epidemiological characteristics of HIV infection in the Lipetsk Region in 1993-2005].

The spread routes of HIV infection in the Lipetsk Region showing a low incidence of this infection rate are analyzed in detail. The findings indicate that the trend in identification of HIV-infected persons in this region reflects the all-Russian HIV-infection spread situation, but the epidemic process has a number of features.