Biopolymeric film containing bioactive naphthoquinone (shikonin) in combined therapy of inflammatory destructive lesions in the buccal mucosa.

Clinical morphological efficiency of local application of a new biopolymeric film was studied. The film was based on methylcellulose derivatives and contained shikonin (preparation of plant origin) and its esters isolated from Lithospermum erythrorhizon L. cell culture.

Pathomorphological and immunohistochemical analysis of proliferative activity of the buccal mucosal epithelium in lichen planus.

Structural reorganization of the buccal mucosa and changes in proliferative activity of epitheliocytes in typical and erosive ulcerative lichen planus were studied. The most manifest diagnostically significant pathomorphological signs of lichen planus of the buccal mucosa are described: acanthosis, granulosis, parakeratosis, lymphocytic infiltration of the lamina propria, and edema. The most pronounced morphological changes and higher index of epitheliocyte proliferative activity (by expression of Ki-67) are characteristic of the erosive ulcerative form of the disease.

[Prevalence of secondary deformities of dentition and diseases of temporomandibular joint in the population of Far East].

Epidemiological survey of 1161 indigenous people (I group) and 1000 people came (II group) of the population of Far East in the age over than 20 years was conducted. Established that the deformation of dentitions at diagnosis was found in 22.13% I group, 20.

Morphological and immunological analysis of the oral mucosa in tobacco smoking and odontopreparation.

Tobacco smoking causes pronounced structural reorganization of the gingival mucosa and its atrophic changes. Odontopreparation stimulates destructive processes in the gingival mucosa promoting activation of local immunity (stimulation of immunoglobulin synthesis). Significant differences in the local humoral immunity (IgG dysimmunoglobulinemia) and cytokine spectrum in nonsmoking and tobacco-smoking patients were detected.