[Effect of losartan, lisinopril and their combination on hemodynamics and morphofunctional parameters of the heart in patients with chronic cardiac failure].

The aim of the study was to evaluate effects of losartan receptor I antagonist (AT) and/or angiotensin converting enzyme inhibitor (iACE) on clinical manifestations of the disease, hemodynamic characteristics, morphofunctional heart parameters in patients with chronic cardiac insufficiency (CHI) complicating coronary heart disease (CHD). A total of 60 patients aged 48-72 (mean 62 +/- 8.4) years with persistent symptoms of functional class II-IV CHI and left ventricular (LV) fraction = < 45% complicating CHD.