[Association of glutathione S-transferase gene polymorphism with risk of male infertility in Moscow region].

Unlabelled: About 30% of male infertility is associated with genetic abnormalities. Genetic polymorphisms increase the level of individual susceptibility to adverse environmental factors and affect human reproductive function.

Aim: To study associations of glutathione S-transferase GSTP1(Ile/Val) gene polymorphisms (A313G; rs1695) with the risk of pathospermia in men of the Moscow region.

[The effect of polymorphisms C677T and 1298 gene MTHFR on the reproductive function of men].

Unlabelled: References. Disturbances of spermogram parameters are associated with infertility in men and are determined by polymorphisms of many genes involved in spermatogenesis. Folate metabolism plays an important role in spermatogenesis, as it is involved in the synthesis, repair and methylation of DNA.