[Unidirectionality of elemental state disorders in workers contacting arsenic compounds and in oncologic patients].

The authors determined concentrations of 24 elements in hair of workers contacting arsenic high concentrations in workplace air, of individuals suffering from malignancies variable in localization, and of general population residing in places with environmentally high level of arsenic. Individuals with high hair content of arsenic and certain elemental dysbalance (sharp decrease of elements ratio Si/Hg, Zn/Hg, Se/Hg, P/Hg, Ni/Hg and Nb/Hg, if compared to control group) were assigned to high risk group for malignancies development.

[Metalloligand homeostasis: molecular basis of iatrogenic and technogenic trace element deficiency].

It is well known that a toxic effect of some medicines is the result of their in vivo interactions with trace elements leading to disturbance of trace element balance in the living body. The Mossbauer spectrometry technique has been used for toxicochemical evaluation of iron-bearing medicines. This method can be used in forensic toxicology.

[An evaluation of the prognostic significance of antigen CD95(Fas/APO-1) expression on the cells of patients with a myelodysplastic syndrome, acute myeloid leukemia and chronic myeloleukemia].

Aim: The expression of CD95(Fas/APO-1) antigen was studied on bone marrow cells of 19 MDS patients, peripheral blood blast cells of 15 acute myeloid leukemia (AML) patients, blast cells and granulocytes of 68 patients with chronic myeloid leukemia (CML)--24 in chronic, 9 in accelerated phase and 35 in blastic crisis (BC)--by indirect surface immunofluorescence assay using flow cytometry (FACScan, Becton Dickinson, USA).

Results: CD95(Fas/APO-1) antigen was revealed on bone marrow cells of 8 out of 19 (36.8%) MDS patients; the percentage of antigen-positive cells was 38.

[The empirical antibiotic therapy of patients with acute leukemias: the results of a multicenter study].

Aim: To evaluate efficacy of ampicilline/sulbactame and fluconasole in the regimen of empirical antibiotic therapy in patients with acute leukemia.

Materials And Methods: The trial covered 14 hematological departments of Russia and 1 of Ukraine. Acute myeloid leukemia patients were included.

[A comparative clinico-morphological analysis of acute myelo- and myelomonoblastic leukemias in children and adults].

Previous morphocytochemical, immunological and cytogenetic analyses of blast cells in 174 children and 188 adults admitted to Cancer Research Center have shown that compared to adults in children leukemic precursors belong to earlier stage of differentiation similar to polypotent cell. The analysis covered 2 FAB-variants of ANLL comparable by the number of patients and intensity of the given chemotherapy (M2 and M4 ANLL FAB variants). The study included 65 children (50 with M2 and 15 with M4 FAB variants) and 43 adults (26 with M2 and 17 with M4 FAB variants) given therapy of standard intensity in the regimen 3+7 and 2+5.