Publications by authors named "G I Fishman"
Article Synopsis
- * Researchers identified 21 human ITPR1 GOF variants and created a mouse model with one of these variants (ITPR1-W1457G), which was found to be prone to stress-induced ventricular arrhythmias.
- * Both mouse models and human data suggest that ITPR1 GOF variants increase Ca handling abnormalities and arrhythmia risk, with 7 rare ITPR1 variants in a human database showing similar GOF behavior linked to cardiac
Article Synopsis
- Glycemic control during critical illness is crucial, with recommendations suggesting insulin therapy for glucose levels over 180 mg/dL, and possibly lowering it to 140 mg/dL for non-diabetics; this study explored the relationship between different glucose thresholds and 90-day mortality.
- A retrospective study analyzed data from 1,429 critical patients, revealing that diabetic individuals had higher mean glucose levels and mortality rates compared to non-diabetics.
- The findings indicated that non-diabetic patients with glucose levels exceeding 150 mg/dL were at a greater risk of mortality within 90 days, highlighting the importance of managing hyperglycemia in this group.
Article Synopsis
- Hypophosphatemia is a significant concern in critically ill patients receiving nutritional support, with over 59% of studied patients developing the condition.
- Factors such as age, BMI, pre-existing diabetes, and certain admission conditions were linked to a lower risk of developing hypophosphatemia, while trauma increased the risk.
- Interestingly, hypophosphatemia was found to be associated with a decreased risk of mortality, though factors like age and specific health scores remained critical indicators of ICU mortality.
Background: Cancer diagnoses often begin with consultations with GPs, but the non-specific nature of symptoms can lead to delayed diagnosis. Unexpected weight loss (UWL) is a common non-specific symptom linked to undiagnosed cancer, yet guidelines for its diagnostic assessment in general practice lack consistency.
Aim: To synthesise evidence on the association between UWL and cancer diagnosis, and to review clinical guidelines and recommendations for assessing patients with UWL.