Publications by authors named "G I Eyjolfsson"
Article Synopsis
- Immunoglobulin G (IgG) is the primary type of antibody in human blood and exists in four subclasses (IgG1 to IgG4), which are influenced by specific genes.
- A genome-wide association study involving 4,334 adults and 4,571 children identified ten new variants and confirmed four known variants linked to IgG subclass levels, affecting conditions like asthma and autoimmune diseases.
- Significant links were found between certain genetic allotypes and specific IgG subclasses, with notable findings showing that lower IgG4 levels can both protect against childhood asthma and increase the risk of inflammatory bowel disease.
Long-read sequencing (LRS) promises to improve the characterization of structural variants (SVs). We generated LRS data from 3,622 Icelanders and identified a median of 22,636 SVs per individual (a median of 13,353 insertions and 9,474 deletions). We discovered a set of 133,886 reliably genotyped SV alleles and imputed them into 166,281 individuals to explore their effects on diseases and other traits.
View Article and Find Full Text PDFBackground: Loss-of-function mutations in the LDL (low-density lipoprotein) receptor gene () cause elevated levels of LDL cholesterol and premature cardiovascular disease. To date, a gain-of-function mutation in with a large effect on LDL cholesterol levels has not been described. Here, we searched for sequence variants in that have a large effect on LDL cholesterol levels.
View Article and Find Full Text PDFAsthma is one of the most common chronic diseases affecting both children and adults. We report a genome-wide association meta-analysis of 69,189 cases and 702,199 controls from Iceland and UK biobank. We find 88 asthma risk variants at 56 loci, 19 previously unreported, and evaluate their effect on other asthma and allergic phenotypes.
View Article and Find Full Text PDFArticle Synopsis
- Lp(a) is a risk factor for cardiovascular diseases, with its molar concentration being more significant than apo(a) size in contributing to this risk.
- A study involving over 143,000 Icelanders found that higher Lp(a) levels are linked to various cardiovascular conditions, while low levels may increase the risk of type 2 diabetes (T2D).
- Reducing Lp(a) levels in individuals with the highest concentrations could potentially lower coronary artery disease (CAD) risk without raising the risk of T2D.