An model for cardiac organoid production: The combined role of geometrical confinement and substrate stiffness.

Induced pluripotent stem cells (iPSCs), carrying the patient's genetic background, open the path to advanced modeling. The feasibility of recapitulating complex pathophysiological scenarios depends on iPSC's ability to differentiate into the plurality of specific organ resident cells, on their maturation and networking. To this end, a strong interest has arisen in organoids, 3D structures, obtained by exploiting iPSC natural capability to self-assemble and rebuild organ parts.

Assessment of the performances and limitations of spacetime convective corrections for acoustic metacontinua design.

The acoustic metamaterial extension to aeroacoustic applications is still an open issue principally due to the lack of a reliable methodology for the meta-devices design when they have to operate in a non-quiescent medium. One suitable strategy is to use spacetime coordinate transformations that include the background flow features to tune the meta-device design parameters analytically, and, therefore, the phenomenon must be reinterpreted into the spacetime. However, a change of coordinates capable of including all the convective effects is not known for general flow conditions and analytical approximations are inevitably introduced.

Health and Economic Advantages Associated With the Use of TachoSil: An Update of Systematic Review.

Background: The international scientific literature is systematically analyzed in this review over a period of nearly 10 years with respect to the use of the active hemostat and surgical sealant patch TachoSil, considering its economic effects. It`s an update of the first review published in 2014.

Methods: A PubMed systematic literature review was done from Nov 2013 up to December 2022.

Optimized workflow for paroxysmal atrial fibrillation ablation using very high power short duration.

Background: wide antral pulmonary vein isolation (PVI) is effective for treating paroxysmal atrial fibrillation (PAF), although time-demanding. We investigated the impact of a standardized ablation protocol by using a bidirectional transeptal steerable sheath, high-density mapping and very high-power-short-duration (vHPSD) catheters on procedure timing, efficacy, and safety.

Methods: consecutive PAF patients free from previous ablations undergoing PVI alone between January 2022 and March 2023 were prospectively enrolled.

Kinetic Pathways to Gelation and Effects of Flow-Induced Structuring in Depletion Gels.

The kinetic pathways to gelation and the effects of flow-induced restructuring are studied here in depletion flocculated gels with short-ranged attractions, both experimentally and using computer simulations. In the experiments, we first carefully diffuse a screening organic salt to destabilize colloid-polymer mixtures and form a gel. We hence avoid flow history effects, typical of traditional mixing protocols.