Publications by authors named "G I Baroncelli"
Article Synopsis
- - The study investigates dental issues in patients with X-linked hypophosphatemic rickets (XLH), focusing on abscess occurrence and the characteristics of pulp chambers.
- - Researchers analyzed 24 XLH patients and 23 healthy controls, using imaging and histological techniques to compare pulp chamber features and dental health.
- - Results showed that most XLH patients have enlarged and altered pulp chambers, increasing their risk for abscesses, highlighting the need for early, multidisciplinary dental care for these patients.
Background And Objective: X-linked hypophosphatemic rickets (XLH) is due to loss-of-function mutations in the phosphate-regulating endopeptidase homologue on the X chromosome (PHEX) that lead to increased fibroblast growth factor 23 (FGF23) production. FGF23 excess causes renal phosphate wasting and insufficient 1,25-dihydroxyvitamin D (1,25(OH)D) synthesis with reduced intestinal phosphate absorption, ultimately resulting in chronic hypophosphatemia. Children with XLH show typical skeletal lesions of rickets, deformities of the lower limbs, stunted growth with disproportionate short stature, bone pain, and physical dysfunctions.
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Purpose: The objective of this systematic review was to determine a minimum serum 25-hydroxyvitamin D (25OHD) threshold based on the risk of having rickets in young children. This work was commissioned by the WHO and FAO within the framework of the update of the vitamin D requirements for children 0-3 years old.
Methods: A systematic search of Embase was conducted to identify studies involving children below 4 years of age with serum 25OHD levels and radiologically confirmed rickets, without any restriction related to the geographical location or language.