Publications by authors named "G Huppertz-Hauss"
Background And Aims: The emergence of biologic therapy has coincided with a decline in surgery rates for Crohn's disease (CD). This study aims to describe the disease course, including intra-abdominal surgery rates, biologic therapy use, and variables associated with biologic therapy initiation in a cohort of newly diagnosed CD patients.
Methods: The Inflammatory Bowel Disease in South-Eastern Norway (IBSEN) III study is a population-based inception cohort study.
Background And Aims: Fatigue is commonly observed in Crohn's disease (CD) and ulcerative colitis (UC), but its association to achieving remission is not clearly established. In this study we describe the odds for fatigue in patients with CD/UC one year after diagnosis based on different definitions of remission and identified factors associated with chronic fatigue (CF) among patients in endoscopic/radiological remission.
Methods: Patients ≥18 years with CD/UC were recruited from the IBSEN III cohort.
Background And Aims: Women with Lynch Syndrome (LS) have a high risk of colorectal and endometrial cancer. They are recommended regular colonoscopies, and some choose prophylactic hysterectomy. The aim of this study was to determine the impact of hysterectomy on subsequent colonoscopy in these women.
View Article and Find Full Text PDFArticle Synopsis
- The introduction of biologic therapies combined with a 'treat-to-target' strategy may have positively influenced the progression of ulcerative colitis (UC) in newly diagnosed patients.
- A study involving 877 adult patients with UC showed that a significant portion was in remission after one year, with low rates of disease progression and colectomy.
- The findings suggest that early treatment with biologics correlates with better outcomes, highlighting the importance of timely intervention in managing UC.
Improved biomarkers are needed for pediatric inflammatory bowel disease. Here we identify a diagnostic lipidomic signature for pediatric inflammatory bowel disease by analyzing blood samples from a discovery cohort of incident treatment-naïve pediatric patients and validating findings in an independent inception cohort. The lipidomic signature comprising of only lactosyl ceramide (d18:1/16:0) and phosphatidylcholine (18:0p/22:6) improves the diagnostic prediction compared with high-sensitivity C-reactive protein.
View Article and Find Full Text PDF