Diagnosis of Ovarian Carcinoma Homologous Recombination DNA Repair Deficiency From Targeted Gene Capture Oncology Assays.

Purpose: Homologous recombination DNA repair deficiency (HRD) is a therapeutic biomarker for sensitivity to platinum and poly(ADP-ribose) polymerase inhibitor therapies in breast and ovarian cancers. Several molecular phenotypes and diagnostic strategies have been developed to assess HRD; however, their clinical implementation remains both technically challenging and methodologically unstandardized.

Methods: We developed and validated an efficient and cost-effective strategy for HRD determination on the basis of calculation of a genome-wide loss of heterozygosity (LOH) score through targeted, hybridization capture and next-generation DNA sequencing augmented with 3,000 common, polymorphic single-nucleotide polymorphism (SNP) sites distributed genome-wide.

Analysis of the antifungal potential of extract against .

To investigate the antifungal potential of extracts against . Extracts were obtained as aqueous (EfraMat-22 and EfraMat-45) and methanolic/ethyl acetate fractions. Broth microdilution and disk diffusion assays showed that EfraMat-45 provided the best results in terms of minimum inhibitory concentration.

Multi-Layer and Conformally Integrated Structurally Embedded Vascular Antenna (SEVA) Arrays.

This work presents the design and fabrication of two multi-element structurally embedded vascular antennas (SEVAs). These are achieved through advances in additively manufactured sacrificial materials and demonstrate the ability to embed vascular microchannels in both planar and complex-curved epoxy-filled quartz fiber structural composite panels. Frequency-reconfigurable antennas are formed by these structures through the pressure-driven transport of liquid metal through the embedded microchannels.

Transitioning from Intraligand π,π* to Charge-Transfer Excited States Using Thiophene-Based Donor-Acceptor Systems.

A series of electron donor-acceptor compounds are reported in which both the donor and acceptor strengths are systematically altered using mono-, bi-, and terthiophene as donors and benzo[][1,2,5]thiadiazole (btd), dipyrido[3,2-:2',3'-]phenazine (dppz), and the corresponding rhenium(I) complex, [ReCl(CO)(dppz)], as acceptors. The electronic properties of the compounds are characterized using electrochemistry, electronic absorbance and emission spectroscopies, and transient absorption spectroscopy. The effect of donor and acceptor strengths on frontier molecular orbital localization and on the charge-transfer (CT) character of optical transitions is modeled using density functional theory (DFT) calculations.

Origami-Inspired Frequency Selective Surface with Fixed Frequency Response under Folding.

Filtering of electromagnetic signals is key for improved signal to noise ratios for a broad class of devices. However, maintaining filter performance in systems undergoing large changes in shape can be challenging, due to the interdependency between element geometry, orientation and lattice spacing. To address this challenge, an origami-based, reconfigurable spatial X-band filter with consistent frequency filtering is presented.