- Antibiotics are commonly overprescribed for acute exacerbations of COPD (AECOPD), prompting the need for biomarkers to help clinicians distinguish between bacterial and non-bacterial causes of exacerbations.
- The study reviewed 39 papers on 61 biomarkers and found that serum C-reactive protein (CRP) and procalcitonin (PCT) show moderate evidence in identifying bacterial infections related to AECOPD, with higher averages noted in patients with bacterial pathogens.
- Overall, while CRP and PCT can help differentiate bacterial from non-bacterial AECOPD, there is a lack of strong evidence for other biomarkers, highlighting the need for more high-quality studies in this area.