Ozone management in Colorado: Why aren't we there yet?

We evaluate why the State Implementation Plan (SIP) process has failed to achieve the attainment of the ozone standards in the Denver Metropolitan and North Front Range Area. Specifically, through interviewing several experts we identified several problems, namely: 1) errors in emissions inventories and modeling of ozone levels that have resulted in incorrect determinations that the ozone standards would be met with proposed emissions controls, and 2) structural problems in the way the SIP process is organized in Colorado, and the lack of political leadership.

Host-pathogen interactions of emerging zoonotic viruses: bats, humans and filoviruses.

This paper provides an overview of the phenomena of cross-species transmission of viruses (known as spillover), focusing on the highly pathogenic filovirus family and their natural reservoir: bats. It also describes the host-pathogen relationship of viruses and their reservoirs, in addition to humans, and discusses current theories of persistent infection.

The Brain Image Library: A Community-Contributed Microscopy Resource for Neuroscientists.

Advancements in microscopy techniques and computing technologies have enabled researchers to digitally reconstruct brains at micron scale. As a result, community efforts like the BRAIN Initiative Cell Census Network (BICCN) have generated thousands of whole-brain imaging datasets to trace neuronal circuitry and comprehensively map cell types. This data holds valuable information that extends beyond initial analyses, opening avenues for variation studies and robust classification of cell types in specific brain regions.

Performance of an envelope glycoprotein-based multiplex immunoassay for Ebola virus antibody detection in a cohort of Ebola virus disease survivors.

Serological surveillance in animal and human hosts can be a cost-effective strategy for orthoebolavirus detection, but is challenged by accurate estimates of seroprevalence, potential pauci-symptomatic disease presentation, and antigenic cross-reactivity. Here, we describe the use of an envelope glycoprotein (GP)-based multiplex microsphere immunoassay, consisting of nine filovirus GP antigens for the detection of anti-Ebola virus (EBOV) antibodies in a well-characterized cohort of Guinean Ebola virus disease (EVD) survivors and contacts from the 2013 - 2016 West African EVD outbreak. We examined sensitivity and specificity for the detection of anti-EBOV antibodies by GP expressed as recombinant trimeric ectodomains, yielding an assay performance of 95.