An immunogenetically defined and immunodominant Trypanosoma cruzi antigen.

Two strains of mice, A. SW (H-2s) and A.CA (H-2f), were immunized with live trypomastigotes or epimastigotes of the Tulahuen strain of Trypanosoma cruzi or with their sonicates.

Non-lytic antibodies in H-2-controlled resistance to acute infection with Trypanosoma cruzi.

1. Resistance to acute Trypanosoma cruzi infection in mice is a polygenic character with a major factor linked to the murine major histocompatibility system (H-2). We found that F1 hybrids A.