Publications by authors named "G Hirasawa"
Article Synopsis
- - Maternal nutritional status, particularly a high-fat diet (mHFD), significantly impacts the development and health of offspring, leading to increased deformities during embryonic development.
- - In a study using medaka fish, mHFD was linked to alterations in mature egg contents, including decreased catabolism of amino acids and increased lipid levels, affecting transcriptomic and metabolomic profiles.
- - The findings suggest that poor egg quality, characterized by lower yolk protein and disrupted metabolic processes, plays a crucial role in causing higher rates of deformities in offspring from mothers on a high-fat diet.
Article Synopsis
- A study examined the effects of strain Shirota (LcS) on mental performance and psychological balance through the gut-brain connection, focusing on healthy office workers with sleep issues.
- Participants consumed fermented milk with LcS and a placebo for 4 weeks each, with evaluations of mood, attention, and brain activity (EEG) conducted during the final week.
- Results showed that LcS improved afternoon attention scores and reduced theta brain activity, indicating potential benefits for daytime performance and overall physiological state.
Background/aims: The basic principle of treatment of congestive heart failure is achieving adequate control of preload and afterload through enhancement of cardiac contractility. In severe cases, however, we have usually applied continuous hemodiafiltration (CHDF) as a type of mechanical support. In this study, we investigated hemodynamic changes caused by CHDF in patients with congestive heart failure.
View Article and Find Full Text PDFEstrogens are important for normal bone growth and metabolism. The mechanisms are incompletely understood. Thus, we have undertaken characterization of the skeletal phenotype of aromatase (ArKO) deficient mice.
View Article and Find Full Text PDFThe 17 beta-hydroxysteroid dehydrogenases (17 beta HSDs) play an important role in the regulation of intracellular levels of biologically active sex steroid hormones in various human tissues. To date, eight distinctive 17 beta HSD enzymes have been cloned and characterized in humans. Among these isoenzymes, 17 beta HSD type 2 (17 beta HSD2) catalyses the conversion of testosterone into androstenedione and/or oestradiol into oestrone in various tissues, and it has thus been suggested to be involved in the biological inactivation of these sex steroids.
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