Publications by authors named "G Hewitt"
Objective: Patients with anorectal malformations (ARMs) may have concurrent gynecologic abnormalities. As patients grow, they typically transition from pediatric subspeciality care and seek adult obstetrics and gynecology (OB/GYN)-related services. We aimed to assess adult OB/GYN physicians' knowledge, competency, and comfort regarding meeting the sexual and reproductive health care needs of patients with ARMs.
View Article and Find Full Text PDFArticle Synopsis
- There is currently no standardized grading system for pediatric female genital trauma (PFGT), leading to potential overuse of medical resources based on injury severity. A high-volume trauma center aimed to address this by analyzing treatment patterns and outcomes and developing a new grading system to improve management decisions.
- A study of 353 female patients under 19 years old with genital trauma revealed that lower-grade injuries (grades 1 and 2) rarely needed surgical repair and primarily utilized local sedation, while higher-grade injuries (grades 5 and 6) typically required more intensive surgical intervention and general anesthesia.
- The proposed management algorithm recommends minimal surgical intervention for lower-grade injuries and encourages surgical consultation for higher-grade
Study Objective: Mullerian duct anomalies are common in females with anorectal malformations (ARMs), although there are no universally recommended screening protocols for identification. Historically, at our institution, we have recommended a screening pelvic ultrasound (PUS) 6 months after thelarche and menarche. We aimed to evaluate outcomes associated with our post-thelarche screening PUS in females with ARMs.
View Article and Find Full Text PDFStudy Objectives: Recommendations from the Children's Oncology Group Long-Term Follow-Up (COG-LTFU) Guidelines for Survivors of Childhood, Adolescent, and Young Adult Cancer emphasize the importance of reproductive health care, yet little is known regarding adherence to these recommendations and non-fertility-related sexual and reproductive health (SRH) outcomes.
Methods: Follow-up of outcomes on the basis of the COG-LTFU guidelines was assessed in female patients who underwent fertility preservation consultation before gonadotoxic therapy between 2016 and 2022 at a single institution and were at least 6 months from treatment completion.
Results: We included 140 patients, with a mean time of 2.
Repair of DNA damage is essential for the maintenance of genome stability and cell viability. DNA double strand breaks (DSBs) constitute a toxic class of DNA lesion and multiple cellular pathways exist to mediate their repair. Robust and titratable assays of cellular DSB repair (DSBR) are important to functionally interrogate the integrity and efficiency of these mechanisms in disease models as well as in response to genetic or pharmacological perturbations.
View Article and Find Full Text PDF