Publications by authors named "G Heuff"
Purpose: The aim of this study is to assess cost-effectiveness of general practitioner (GP) versus surgeon-led colon cancer survivorship care from a societal perspective.
Methods: We performed an economic evaluation alongside the I CARE study, which included 303 cancer patients (stages I-III) who were randomised to survivorship care by a GP or surgeon. Questionnaires were administered at baseline, 3-, 6-, 12-, 24- and 36-months.
Ferric carboxymaltose infusion versus oral iron supplementation for preoperative iron deficiency anaemia in patients with colorectal cancer (FIT): a multicentre, open-label, randomised, controlled trial.
Lancet Haematol
April 2023
Background: A third of patients with colorectal cancer who are eligible for surgery in high-income countries have concomitant anaemia associated with adverse outcomes. We aimed to compare the efficacy of preoperative intravenous and oral iron supplementation in patients with colorectal cancer and iron deficiency anaemia.
Methods: In the FIT multicentre, open-label, randomised, controlled trial, adult patients (aged 18 years or older) with M0 stage colorectal cancer scheduled for elective curative resection and iron deficiency anaemia (defined as haemoglobin level of less than 7·5 mmol/L (12 g/dL) for women and less than 8 mmol/L (13 g/dL) for men, and a transferrin saturation of less than 20%) were randomly assigned to either 1-2 g of ferric carboxymaltose intravenously or three tablets of 200 mg of oral ferrous fumarate daily.
Article Synopsis
- - In the I CARE study, colon cancer patients were assigned to receive follow-up care from either general practitioners (GPs) or surgeons to analyze the impact on recurrence detection and time to recurrence.
- - Out of 303 patients, slightly more recurrences were detected in the surgeon group compared to the GP group, but the difference was minimal and both groups showed similar outcomes in terms of mortality rates.
- - The study concluded that follow-up care from GPs is just as effective as that from surgeons for detecting cancer recurrences and does not result in significant differences in patient survival rates.
Article Synopsis
- Abdominoperineal resection (APR) for rectal cancer traditionally uses primary perineal wound closure, but new methods like the gluteal turnover flap may enhance healing by providing well-vascularized tissue without donor site scars.
- This multicenter randomized controlled trial will involve 160 patients undergoing APR, comparing the gluteal flap technique to standard closure, with patients and assessors blinded to the technique used.
- The primary goal is to determine the rate of uncomplicated perineal wound healing at 30 days, with secondary measures including complications, quality of life, and urogenital function, aiming to increase healing rates significantly from 65% to 85%.
Purpose: We evaluated the effect of Internet-based cognitive behavioral therapy (iCBT), with or without therapist support, on the perceived impact of hot flushes and night sweats (HF/NS) and overall levels of menopausal symptoms (primary outcomes), sleep quality, HF/NS frequency, sexual functioning, psychological distress, and health-related quality of life in breast cancer survivors with treatment-induced menopausal symptoms.
Patients And Methods: We randomly assigned 254 breast cancer survivors to a therapist-guided or a self-managed iCBT group or to a waiting list control group. The 6-week iCBT program included psycho-education, behavior monitoring, and cognitive restructuring.