Publications by authors named "G Hery"
Objective: To assess the incidence of posthepatectomy liver failure (PHLF) and the role of the future liver remnant (FLR) in children undergoing major hepatectomy.
Summary Background Data: Incidence and risk factors of PHLF in children are unclear, with no validated definition for this age group. Consequently, the role of the FLR in pediatric hepatectomy and evidence-based preoperative guidelines remain undefined.
Background/objectives: In paediatric liver transplantation, donor-recipient compatibility depends on graft size. We explored whether the graft weight can be predicted using the donor's biometric parameters.
Methods: We used seven easily available biometric variables in 142 anonymised paediatric and adult donors, with data collected between 2016 and 2022.
Article Synopsis
- There is currently a lack of comparative studies on liver transplantation (LT) versus liver resection (LR) for locally advanced hepatoblastoma, resulting in a significant evidence gap that complicates the development of treatment guidelines.
- In a systematic review, 189 patients from 55 studies were analyzed, comparing outcomes between those undergoing LT and those who received LR, showing differing rates of local and distant recurrence but similar overall and event-free survival rates for both treatments.
- The findings indicate that LR is a viable alternative to LT for these patients, as the outcomes are comparable and both treatments have favorable results.
Article Synopsis
- * A study from a tertiary care center between 2010 and 2022 revealed a significant increase in cases (3.3-fold) during the SARS-CoV-2 pandemic compared to pre-pandemic years, though liver characteristics remained similar across both periods.
- * Early initiation of immunosuppressive therapy was noted during the pandemic, and conducting liver biopsies is recommended for undetermined acute hepatitis cases, even if autoimmune antibodies are negative.
Article Synopsis
- - Recent studies suggest that systemic infections, like COVID-19, may worsen Alzheimer's disease (AD) in vulnerable aging populations, prompting this research on brains from AD patients who survived COVID-19 compared to those who did not.
- - Post-mortem analysis revealed that COVID-AD patients exhibited higher levels of amyloid beta (Aβ) in specific brain regions and significant disruptions in microglial and astrocytic function compared to non-COVID AD patients.
- - Findings indicate lasting effects of COVID-19 on neuroimmune responses and glial health in AD patients, potentially contributing to disease progression long after infection, particularly involving pathways related to myelination and oligodendrocyte dysregulation.