Publications by authors named "G Hernandez-Peredo"
Esophageal Acid clearance: more volume-dependent than motility-dependent in healthy piglets.
J Pediatr Gastroenterol Nutr
August 2002
Background/aims: The present study investigates manometrically in healthy piglets whether esophageal clearance after distension with different volumes of acid is volume-dependent.
Methods: Sedated, non-intubated piglets (n = 22) underwent stationary manometry of the esophagus with a 4-probe perfused assembly after successive injection of 1, 2, and 3 mL of saline and acid. Simultaneous pH metering allowed assessment of acid clearance.
Background/purpose: The lower esophageal sphincter and the diaphragmatic crural sling form the gastroesophageal barrier. This work shows that division of the sphincteric component alone suffices to induce reflux esophagitis in piglets.
Methods: Male piglets underwent either sham operation (n = 7) or extramucosal myotomy of the gastroesophageal junction (n = 8).
We describe the anatomy and function of the gastroesophageal barrier in the piglet. Male piglets underwent dissection (N = 6) and gastroesophageal muscle layer histometry (N = 6). Sedated, nonintubated animals (N = 13) underwent four-probe perfusion esophageal manometry and the pressure profiles were related to the muscular thickness in the four quadrants.
View Article and Find Full Text PDFBackground/purpose: This report identifies a group of children in whom severe acute food bolus impaction (AFBI) was the leading symptom of gastroesophageal reflux (GER) in the absence of stricture.
Methods: The esophageal structure and function of 8 patients treated for AFBI requiring endoscopic removal of alimentary foreign bodies in 6 of them (up to 4 times in 1 case) were investigated by barium meal, esophagoscopy-biopsy, pH-metering, pull-through stationary manometry, and 24-hour ambulatory manometry. The results were compared with those in a group of age-matched regular refluxers (n = 14) without AFBI.