Development and evaluation of an inventory for rating client satisfaction with outcome in HIV counseling: the Albion Center scale.

We developed an inventory for rating client satisfaction with outcome in HIV counseling, based on interview responses with clients. The resulting 19-item scale was subject to factor analysis and four factors, accounting for 56% of the variance, emerged. The factors described dimensions of Perception of progress and improved mood; Recognition of a specific need for counseling; Behavior change from counseling; and Counseling climate.

Effect time-course of the inhibition of histamine induced skin reactions by orally applied dimethindene maleate.

We have investigated the time-course of the flare inhibiting activity of dimethindene maleate in man and compared the resulting effect-kinetic data with those from pharmacokinetic investigations. The study was carried out in a double-blind, placebo-controlled cross-over design with randomly assigned healthy volunteers. Dimethindene maleate (4 mg) was orally applied, followed by intracutaneous histamine provocations (-1, 2, 5, 14, 17, 20, 23, 26, 29 h).

Time course of the anti-oedematous effect of O-(beta-hydroxyethyl)-rutosides in healthy volunteers.

O-(beta-hydroxyethyl)-rutosides (HR) is used for the treatment of disorders of the venous and microcirculatory systems. In order to evaluate the time course of its activity, the effect of HR on a provocation model of orthostatic oedema in healthy volunteers was used. After a 2 week placebo run-in period, 16 healthy volunteers were randomized to HR (2 tablets of 500 mg/day) of placebo for a further 3 weeks, in a double-blind parallel design.

Variations of skin sensitivity to intracutaneous histamine provocations with regard to provocation time.

Dermal provocation tests with histamine and other mediators of allergy are widely used as diagnostic tools and as clinical pharmacological models. Diurnal variations of skin reactivity e.g.

Effect-time-relation of the H1-receptor antagonist dimethindene maleate following intravenous injection.

We have investigated the time-course of the weal and flare inhibiting activity of dimethindene maleate in man and compared the resulting effect-kinetic data with those from pharmacokinetic investigations. The study was carried out in a double blind, placebo controlled cross-over design with randomly assigned healthy volunteers. Dimethindene maleate (4 mg) was intravenously injected, followed by intracutaneous histamine provocations (-1, 2, 5, 14, 17, 20, 23, 26, and 29 h).