Ultrasound-guided breast-conserving surgery compared to conventional breast-conserving surgery.

Purpose: The goal of breast-conserving surgery is to achieve negative tumor margins, since insufficient marginal distance is associated with more local and distant recurrences. This study investigates whether IOUS (intraoperative ultrasound) can reduce the re-resection rate compared to standard breast surgery, regardless of tumor biology and focality.

Materials And Methods: The present study is a monocentric, prospective, randomized, and non-blinded parallel group study conducted between 7/2015 and 2/2018.

Folate receptor α deficiency - Myelin-sensitive MRI as a reliable biomarker to monitor the efficacy and long-term outcome of a new therapeutic approach.

Cerebral folate transport deficiency, caused by a genetic defect in folate receptor α, is a devastating neurometabolic disorder that, if untreated, leads to epileptic encephalopathy, psychomotor decline and hypomyelination. Currently, there are limited data on effective dosage and duration of treatment, though early diagnosis and therapy with folinic acid appears critical. The aim of this long-term study was to identify new therapeutic approaches and novel biomarkers for assessing efficacy, focusing on myelin-sensitive MRI.

Back to the future: breast surgery with tumescent local anesthesia (TLA)?

Purpose: Breast surgery is usually performed under general anesthesia. Tumescent local anesthesia (TLA) offers the possibility to anesthetize large areas with highly diluted local anesthetic.

Methods: In this paper, the implementation, and experiences with TLA in the field of breast surgery are discussed.

-correction of magnetization transfer saturation maps optimized for 7T postmortem MRI of the brain.

Purpose: Magnetization transfer saturation ( ) is a useful marker to probe tissue macromolecular content and myelination in the brain. The increased -inhomogeneity at  T and significantly larger saturation pulse flip angles which are often used for postmortem studies exceed the limits where previous correction methods are applicable. Here, we develop a calibration-based correction model and procedure, and validate and evaluate it in postmortem 7T data of whole chimpanzee brains.