Publications by authors named "G Heller"
Despite major therapeutic advances in the treatment of acute lymphoblastic leukemia (ALL), resistances and long-term toxicities still pose significant challenges. Cyclins and their associated cyclin-dependent kinases are one focus of cancer research when looking for targeted therapies. We discovered cyclin C as a key factor for B-ALL development and maintenance.
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- Parkinson's disease is a progressive condition that requires new therapies to improve symptoms, and photobiomodulation therapy has shown promise in small studies.
- A five-year follow-up on eight participants from a prior study evaluated the long-term effects of self-applied photobiomodulation therapy, with most continuing treatment throughout this period.
- Results indicated significant improvements in mobility, balance, and cognition for the participants who continued therapy, though some measures, including overall motor function and static balance, showed no significant changes or declines.
Acceptance and willingness of patients with chronic facial nerve palsy for an implantable device that assists with eye closure.
J Plast Reconstr Aesthet Surg
September 2024
Background: Patients with facial nerve palsy often experience lagophthalmos (incomplete eye closure), which can lead to exposure keratitis. The Bionic Lid Implant for Natural Eye Closure (BLINC) is a medical device designed to mimic the more natural blink kinetics than traditional lid loading techniques.
Aims: This study aimed to evaluate potential factors that might influence the design of the BLINC device and willingness of participant to undergo the implant placement surgery.
Intrinsically disordered proteins (IDPs) often contain proline residues that undergo cis/trans isomerization. While molecular dynamics (MD) simulations have the potential to fully characterize the proline cis and trans subensembles, they are limited by the slow timescales of isomerization and force field inaccuracies. NMR spectroscopy can report on ensemble-averaged observables for both the cis-proline and trans-proline states, but a full atomistic characterization of these conformers is challenging.
View Article and Find Full Text PDFIntroduction: This study investigates the relationship between volume, structural characteristics and quality of outcome, specifically for infants at the border of viability.
Methods: Using administrative data of the largest provider of statutory healthcare insurance in Germany between 2010-2015, infants with an admission weight (AW) between 250-1249 g treated initially in perinatal centers were included. For infants at the border of viability (250-499 g AW), the endpoints mortality and mortality or morbidity were analyzed.